The Bio-Nobile™ Magnetic Particle based technology

BN P & S manufactures and distributes globally the Bio-Nobile brand manual and automated solutions for nucleic acid (genomic DNA, plant DNA, total RNA, mRNA), and also reagents for cell and protein purification.

The QuickPick™ SML (Small-Medium-Large - scalable for various sample sizes) DNA purification kits provide a fast and simple means of purifying DNA from a variety of samples. The technique does not require any organic solvents and eliminates the need for repeated centrifugation, vacuum filtration or column separation.

BN P & S also provides various purification and isolation services. Read more about it on the Services page.
Some application examples:
The QuickPick SML Plant DNA purification kit provides a means of purifying genomic DNA  from a variety of plants or their organelles. The  kit generates high-quality DNA from different plant  species. It is possible to  scale  the  kit up-and-down for variuos sample amounts by using different kit reagent volumes. 
Download Technical Note as PDF file
The  QuickPickTM SML genomict DNA kit,  combined with lysozyme  treatment, generates high-quality genomic DNA  from gram-positive Lactobacillus Sp. Purified DNA can be used directly as template for PCR amplification.
Download Technical Note as PDF file
Feathers are a difficult material to isolate DNA from, since only the feather tip contains the DNA.  Attached to the outside are old skin cells, while inside are old blood cells, from when the feather was still growing. However, feathers offer advantages compared to blood samples because they can be collected much earlier from young chicks and DNA analysis can be performed at a very early stage.
Download Technical Note as PDF file
See the full list of available application notes from Bio-Nobile
The Solid Phase Extraction and Liquid / Liquid Extraction from Tomtec
The Quadra 3® SPE sets an even higher standard for Solid Phase Extraction and Liquid / Liquid Extraction BECAUSE:
Products for DNA and RNA purification
Tip has a maximum volume of 450µL, making it the highest volume of any 96 well pipette tip. Fewer transfer passes are required to achieve the higher transfer volumes in sample extraction methods
The long skinny tip end is designed to reach the bottom of deepwell microplates, commonly used in extraction protocols. It also provides a CV of 2% at 10µL.
The ability to blow through the tips with air or nitrogen to purge organic vapour from the tip interior allows aqueous materials to be pipetted with precision after pipetting organics.
Validation in GMP Environments by checksums. The Quadra 3® SPE programs calculate a checksum on the binary code of the program. When that program is recalled, and the checksum matches the original, then the program is an exact duplicate.
Application example:
Typical application is the use of  Millipore’s Montage Plasmid Kit for the Tomtec Quadra 3 with Vacuum Box and Arm. This application and a few others are described in this application note from Tomtec:
Download Application Note as PDF file
Homogenization solutions from Tomtec
Whatever you isolation method is, the success and outcome is highly dependent on the initial preparation steps. A good and reproducible homogenization of the sample is a must. The AUTOGIZER from Tomtec is designed to fully automate a variety of homogenizing tasks. Model 700 is equipped with 5 Model 200  1/5 hp units. Model 701 is equipped with 4 Model 250  3/4 hp units for heavy duty tasks. A wide range of cutter sizes are available for each model. A standard tube rack is included. Custom racks with or without ice baths are readily available.

An opptional Aluminum Hood Enclosure is available to minimize risk of contamination. The hood
• Provides sound and aerosol containment
• Sliding door access - Venting optional
• Easy to assemble and disassemble again when you don't need it for a while
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Small accessories from Tomtec
We offer a range of small but very useful accessories and tools from Tomtec, for example:
• A Solid Phase vacuum manifold
• A vacuum controller module
• A vacuum manifold for Multiscreen filter plates
Ready to use DNA ladders from GeneDireX, stable at room temperature.

For example, the 100bp DNA Ladder (cat No. DM001-R500) contains a unique combination of PCR products and a number of proprietary plasmids digested with appropriate restriction enzymes to yield 11 fragments, suitable for use as molecular weight standards for agarose gel electrophoresis. The DNA includes fragments ranging from
100-1500 base pairs. The 500 and 1500 base pair bands have increased intensity to serve as reference points. The approximate mass of DNA in each band is provided (0.5 µg a load) for approximating the mass of DNA in comparably intense samples of similar size.